A common solution to the cosmic ray anisotropy and gradient problems

Multichannel Cosmic Ray (CR) spectra and the large scale CR anisotropy can hardly be made compatible in the framework of conventional isotropic and homogeneous propagation models. These models also have problems explaining the longitude distribution and the radial emissivity gradient of the $\gamma$-ray galactic interstellar emission. We argue here that accounting for a well physically motivated correlation between the CR escape time and the spatially dependent magnetic turbulence power can naturally solve both problems. Indeed, by exploiting this correlation we find propagation models that fit a wide set of CR primary and secondary spectra, and consistently reproduce the CR anisotropy in the energy range 10^2 - 10^4 \GeV and the $\gamma$-ray longitude distribution recently measured by Fermi-LAT.Comment: 4 pages, 3 figures. v2: Accepted in Phys. Rev. Let

Gamma-ray polarization constraints on Planck scale violations of special relativity

Using recent polarimetric observations of the Crab Nebula in the hard X-ray band by INTEGRAL, we show that the absence of vacuum birefringence effects constrains O(E/M) Lorentz violation in QED to the level |\xi| < 9x10^{-10} at three sigma CL, tightening by more than three orders of magnitude previous constraints. We show that planned X-ray polarimeters have the potential the potential to probe |\xi|~ 10^{-16} by detecting polarization in active galaxies at red-shift ~1.Comment: 4 pages, 3 figure

On Modified Dispersion Relations and the Chandrasekhar Mass Limit

Modified dispersion relations from effective field theory are shown to alter the Chandrasekhar mass limit. At exceptionally high densities, the modifications affect the pressure of a degenerate electron gas and can increase or decrease the mass limit, depending on the sign of the modifications. These changes to the mass limit are unlikely to be relevant for the astrophysics of white dwarf or neutron stars due to well-known dynamical instabilities that occur at lower densities. Generalizations to frameworks other than effective field theory are discussed.Comment: 14 pages, 2 figures; v2: version accepted for publication, minor changes; v3: note added correcting comments on the applicability of the calculation to the DSR context, references added, results unchange

High-resolution bioelectrical imaging of A&#946;-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies

Neurotoxicity and the accumulation of extracellular amyloid-beta1-42 (A\u3b2) peptides are associated with the development of Alzheimer's disease (AD) and correlate with neuronal activity and network dysfunctions, ultimately leading to cellular death. However, research on neurodegenerative diseases is hampered by the paucity of reliable readouts and experimental models to study such functional decline from an early onset and to test rescue strategies within networks at cellular resolution. To overcome this important obstacle, we demonstrate a simple yet powerful in vitro AD model based on a rat hippocampal cell culture system that exploits large-scale neuronal recordings from 4096-electrodes on CMOS-chips for electrophysiological quantifications. This model allows us to monitor network activity changes at the cellular level and to uniquely uncover the early activity-dependent deterioration induced by A\u3b2-neurotoxicity. We also demonstrate the potential of this in vitro model to test a plausible hypothesis underlying the A\u3b2-neurotoxicity and to assay potential therapeutic approaches. Specifically, by quantifying N-methyl D-aspartate (NMDA) concentration-dependent effects in comparison with low-concentration allogenic-A\u3b2, we confirm the role of extrasynaptic-NMDA receptors activation that may contribute to A\u3b2-neurotoxicity. Finally, we assess the potential rescue of neural stem cells (NSCs) and of two pharmacotherapies, memantine and saffron, for reversing A\u3b2-neurotoxicity and rescuing network-wide firing

D-Foam Phenomenology: Dark Energy, the Velocity of Light and a Possible D-Void

In a D-brane model of space-time foam, there are contributions to the dark energy that depend on the D-brane velocities and on the density of D-particle defects. The latter may also reduce the speeds of photons linearly with their energies, establishing a phenomenological connection with astrophysical probes of the universality of the velocity of light. Specifically, the cosmological dark energy density measured at the present epoch may be linked to the apparent retardation of energetic photons propagating from nearby AGNs. However, this nascent field of `D-foam phenomenology' may be complicated by a dependence of the D-particle density on the cosmological epoch. A reduced density of D-particles at redshifts z ~ 1 - a `D-void' - would increase the dark energy while suppressing the vacuum refractive index, and thereby might reconcile the AGN measurements with the relatively small retardation seen for the energetic photons propagating from GRB 090510, as measured by the Fermi satellite.Comment: 10 pages, 3 figure

Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

Multielectrode arrays (MEAs) are extensively used for electrophysiological studies on brain slices, but the spatial resolution and field of recording of conventional arrays are limited by the low number of electrodes available. Here, we present a large-scale array recording simultaneously from 4096 electrodes used to study propagating spontaneous and evoked network activity in acute murine cortico-hippocampal brain slices at unprecedented spatial and temporal resolution. We demonstrate that multiple chemically induced epileptiform episodes in the mouse cortex and hippocampus can be classified according to their spatio-temporal dynamics. Additionally, the large-scale and high-density features of our recording system enable the topological localization and quantification of the effects of antiepileptic drugs in local neuronal microcircuits, based on the distinct field potential propagation patterns. This novel high-resolution approach paves the way to detailed electrophysiological studies in brain circuits spanning spatial scales from single neurons up to the entire slice network

Lorentz Violation of Quantum Gravity

A quantum gravity theory which becomes renormalizable at short distances due to a spontaneous symmetry breaking of Lorentz invariance and diffeomorphism invariance is studied. A breaking of Lorentz invariance with the breaking patterns $SO(3,1)\to O(3)$ and $SO(3,1)\to O(2)$, describing 3+1 and 2+1 quantum gravity, respectively, is proposed. A complex time dependent Schr\"odinger equation (generalized Wheeler-DeWitt equation) for the wave function of the universe exists in the spontaneously broken symmetry phase at Planck energy and in the early universe, uniting quantum mechanics and general relativity. An explanation of the second law of thermodynamics and the spontaneous creation of matter in the early universe can be obtained in the symmetry broken phase of gravity.Comment: 10 pages, minor change and reference added. Typos corrected. To be published in Class. Quant. Grav